Here you are now: you've finally made up your mind! You'll build your first highly interactive SPA! Somehow similar to native mobile and desktop apps, adapted so deliver your users a desktop-like experience. And as quickly as possible, needless to add. So, which single page application framework will you go with? That is the question! And there's no such thing as “the best JavaScript framework” fit for the job, only “the best-suited one for your own project's needs”. So first, you need to get those goals of yours clearly defined!